Measurements of charged-particle distributions with the ATLAS detector

Inclusive charged-particle measurements probe the low-energy region of the non-perturbative quantum chromodynamics. The ATLAS collaboration has recently measured the charged-particle multiplicity and its dependence on transverse momentum and pseudorapidity in special data sets with low LHC beam currents, recorded at centre-of-mass energies of 8 TeV and 13 TeV. The measurements at 8 TeV cover a wide spectrum using charged-particle selections with minimum transverse momentum of both 100 MeV and 500 MeV and in various phase space regions of low and high charged-particle multiplicities, some of which are studied for the first time by ATLAS. The measurements at 13 TeV also present detailed studies with a minimum transverse momentum of both 100 MeV and 500 MeV. The measurements are compared with predictions of various tuned Monte Carlo generators and are found to provide strong constraints on these. None of the Monte Carlo generators with their respective tunes are able to reproduce all the features of the data.Comment: Proceedings of Low-x Meeting 201

A unified approach to the performance analysis of caching systems

We propose a unified methodology to analyse the performance of caches (both isolated and interconnected), by extending and generalizing a decoupling technique originally known as Che's approximation, which provides very accurate results at low computational cost. We consider several caching policies, taking into account the effects of temporal locality. In the case of interconnected caches, our approach allows us to do better than the Poisson approximation commonly adopted in prior work. Our results, validated against simulations and trace-driven experiments, provide interesting insights into the performance of caching systems.Comment: in ACM TOMPECS 20016. Preliminary version published at IEEE Infocom 201

Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies

In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest. Therapeutic interventions that promote tissue and organ regeneration have as primary objective the selective control of gene expression in adult stem cells. This requires a deep understanding of the epigenetic mechanisms controlling transcriptional programs in tissue progenitors. This review attempts to elucidate the principle epigenetic regulations responsible of stem cells differentiation. In particular we focus on the current understanding of the epigenetic networks that regulate differentiation of muscle progenitors by the concerted action of chromatin-modifying enzymes and noncoding RNAs. The novel exciting role of exosome-bound microRNA in mediating epigenetic information transfer is also discussed. Finally we show an overview of the epigenetic strategies and therapies that aim to potentiate muscle regeneration and counteract the progression of Duchenne Muscular Dystrophy (DMD)

Impact of Correlated Mobility on Delay-Throughput Performance in Mobile Ad-Hoc Networks

Abstract—We extend the analysis of the scaling laws of wireless ad hoc networks to the case of correlated nodes movements, which are commonly found in real mobility processes. We consider a simple version of the Reference Point Group Mobility model, in which nodes belonging to the same group are constrained to lie in a disc area, whose center moves uniformly across the network according to the i.i.d. model. We assume fast mobility conditions, and take as primary goal the maximization of pernode throughput. We discover that correlated node movements have huge impact on asymptotic throughput and delay, and can sometimes lead to better performance than the one achievable under independent nodes movements. I. INTRODUCTION AND RELATED WORK In the last few years the store-carry-forward communication paradigm, which allows nodes to physically carry buffered dat

Nonlocal semilinear second-order differential inclusions in abstract spaces without compactness

summary:We study the existence of a mild solution to the nonlocal initial value problem for semilinear second-order differential inclusions in abstract spaces. The result is obtained by combining the Kakutani fixed point theorem with the approximation solvability method and the weak topology. This combination enables getting the result without any requirements for compactness of the right-hand side or of the cosine family generated by the linear operator

The effect of political institutions on the size of government spending in European Union member states and Croatia

This paper presents an overview of theoretical and empirical research on the interaction between political institutions and economic variables. Using the dynamic panel model, the paper also investigates the indirect effects of electoral systems on the size of general government spending. The analysis is performed on a panel dataset of 26 countries (25 member states of the European Union and Croatia) for the period between 1995 and 2010. The results show that government fragmentation and political stability affect the dynamics of budgetary expenditures in line with theoretical assumptions. Regarding the implications of this research for Croatia, it has been shown that a higher degree of government fragmentation leads to an increase in government spending which is a significant result since Croatia has generally had some form of coalition government

Targeting kinases with anilinopyrimidines: Discovery of N-phenyl-N'-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily

Kinase inhibitors are attractive drugs/drug candidates for the treatment of cancer. The most recent literature has highlighted the importance of multi target kinase inhibitors, although a correct balance between specificity and non-specificity is required. In this view, the discovery of multityrosine kinase inhibitors with subfamily selectivity is a challenging goal. Herein we present the synthesis and the preliminary kinase profiling of a set of novel 4-anilinopyrimidines. Among the synthesized compounds, the N-phenyl-N\u2019-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives selectively targeted some members of class III receptor tyrosine kinase family. Starting from the structure of hit compound 19 we synthesized a further compound with an improved affinity toward the class III receptor tyrosine kinase members and endowed with a promising antitumor activity both in vitro and in vivo in a murine solid tumor model. Molecular modeling simulations were used in order to rationalize the behavior of the title compounds

Diagnosis of Occlusal Carious Lesions Using KaVo DIAGNOdent 2095

Svrha je ovoga rada pojasniti način uporabe i utvrditi prednosti KaVo DIAGNOdent 2095 uređaja u kliničkoj detekciji raznih demineralizaciskih promjena u caklini okluzalnih ploha zuba, koje se podrazumjevaju inicijalnom karijesnom lezijom. Znatna prednost KaVo DIAGNOdent laserskoga uređaja temelji se na mogućnosti registracije i vrjednovanja fluorescentnoga zračenja, na načelu emisije pulsirajuće zrake valne duljine 655 nm. Na taj je način omogućen pristup sićušnim područjima okluzalnih caklinskih ploha koje nisu dostupne primjenom drugih dijagnostičkih metoda. Specifičnost i polivalentnost u uporabi temelje se i na mogućnosti dijagnoze dentalnoga plaka, diskoloracija i zubnoga kamenaca. Jednostavnost u rukovanju te pouzdanost i objektivnost kliničkoga nalaza (> 90 %) upućuju na prednosti u usporedbi s kliničkim radiografskim metodama. Ima veliku važnost za postavljanje dijagnoze u planiranju neinvanzivnih postupaka liječenje. Zato se preporučuje češća uporaba uređaja u svakodnevnoj kliničkoj dijagnostici karijesa zbog manje invanzivnoga pristupa u restorativnoj stomatologiji koji omogućuje da se maksimalno očuva zdravo zubno tkivo.The aim of the study was to explain in detail the usage of KaVo DIAGNOdent 2095 and to determine its advantages in clinical detection of early demineralisation of oclusal enamel surfaces, pronounced as initial occlusal caries lesins. The great advantage in diagnosis offered by KaVo DIAGNOdent laser based on its ability to register and evaluate fluorescent emission of the pulsed beam of the 655 nm wavelength. It enables access to the most minute occlusal routes, otherwise unreachable by other means of diagnosing techniques. Specificity and multidimensional approach is based on the pssibility of diagnosin dental plaque, discoloration and calculus. Simplicity and the ability to produce a reliable and objective clinical diagnosis (> 90 %) are the advantages in comparison with classical radiographic methods and inspection using a probe. It is of great importance in planning noninvasive and preventive conservative treatments. It is recommended for use more frequently in everyday clinical diagnosis of caries lesions, because of it’s less invasive approach in restorative dentistry, which leads to preservation of healthy tooth tissue

AMPK in the central nervous system: physiological roles and pathological implications

5′ AMP-activated protein kinase (AMPK) is considered the master metabolic regulator in all eukaryotes, as it maintains cellular energy homeostasis in a variety of tissues, including the brain. In humans, alterations in AMPK activity can lead to a wide spectrum of metabolic disorders. The relevance of this protein kinase in the pathogenesis of diabetes and metabolic syndrome is now well established. On the contrary, correlations between AMPK and brain physiopathology are still poorly characterized. The aim of this review is to summarize and discuss the current knowledge about the prospective involvement of AMPK in the onset and the progression of different neurological diseases